Sex similarities and differences in pain-related periaqueductal gray connectivity
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چکیده
منابع مشابه
PERIAQUEDUCTAL GRAY 1 Running head: PERIAQUEDUCTAL GRAY Common representation of pain and negative emotion in the midbrain periaqueductal gray
Human neuroimaging offers a powerful way to connect animal and human research on emotion, with profound implications for psychological science. However, the gulf between animal and human studies remains a formidable obstacle: Human studies typically focus on the cortex and a few subcortical regions such as the amygdala, whereas deeper structures such as the brainstem periaqueductal gray (PAG) p...
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Chronic low back pain is a common neurological disorder. The periaqueductal gray (PAG) plays a key role in the descending modulation of pain. In this study, we investigated brain resting state PAG functional connectivity (FC) differences between patients with chronic low back pain (cLBP) in low pain or high pain condition and matched healthy controls (HCs). PAG seed based functional connectivit...
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UNLABELLED The ventrolateral periaqueductal gray (vlPAG) is a key structure in the descending pain modulatory circuit. Activation of the circuit occurs via disinhibition of GABAergic inputs onto vlPAG output neurons. In these studies, we tested the hypothesis that GABAergic inhibition is increased during persistent inflammation, dampening activation of the descending circuit from the vlPAG. Our...
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Migraineurs show hypersensitivity to sensory stimuli at various stages throughout the migraine cycle. A number of putative processes have been implicated including a dysfunction in the descending pain modulatory system in which the periaqueductal gray (PAG) is considered to play a crucial role. Recurring migraine attacks could progressively perturb this system, lowering the threshold for future...
متن کاملThe periaqueductal gray and descending pain modulation : Why should we 1 study them and what role do they play in chronic pain ? 2 Running head : Periaqueductal gray connectivity in chronic pain 3
K.S.H. and M.A.C. drafted manuscript; K.S.H. and M.A.C. edited and 8 revised manuscript; K.S.H. and M.A.C. approved final version of manuscript; 9 K.S.H. and M.A.C. prepared figures. 10 11 Corresponding Author: 12 Kasey Hemington 13 [email protected] 14 Toronto Western Hospital 15 Main Pavilion 16 14th Floor Room 14MP301 17 399 Bathurst St. 18 Toronto, Ontario 19 Canada M5T 2S8 20 (41...
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ژورنال
عنوان ژورنال: Pain
سال: 2012
ISSN: 0304-3959
DOI: 10.1016/j.pain.2011.11.006